Photoisomerization Neutralizes Vasoconstrictive Activity of a Heme Degradation Product
نویسندگان
چکیده
منابع مشابه
Degradation of heme in gram-negative bacteria: the product of the hemO gene of Neisseriae is a heme oxygenase.
A full-length heme oxygenase gene from the gram-negative pathogen Neisseria meningitidis was cloned and expressed in Escherichia coli. Expression of the enzyme yielded soluble catalytically active protein and caused accumulation of biliverdin within the E. coli cells. The purified HemO forms a 1:1 complex with heme and has a heme protein spectrum similar to that previously reported for the puri...
متن کاملHeme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450
BACKGROUND & AIMS The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural products, hormones, drugs, and carcinogens. Feline leukemia virus subgroup C cellular receptor 1a (FLVCR1a) is plasma membrane heme exporter that...
متن کاملBilirubin: an endogenous product of heme degradation with both cytotoxic and cytoprotective properties.
Bilirubin is a linear tetrapyrrole that is formed during the process of heme degradation. Heme is released from a series of hemeproteins, including hemoglobin and cytochrome P450, and metabolized by heme oxygenase to form carbon monoxide, biliverdin, and free iron. Biliverdin is subsequently transformed to bilirubin by biliverdin reductase (Fig. 1). Bilirubin is a highly lipophilic molecule des...
متن کاملEstimation of pyrolysis product of LDPE degradation using different process parameters in a stirred reactor
Pyrolysis of low density polyethylene (LDPE) by equilibrium fluid catalytic cracking (FCC) was studied in a stirred reactor under different process parameters. In this work, the effect of process parameters such as degradation temperature (420-510°C), catalyst/polymer ratio (0-60%), carrier gas type (H2, N2, ethylene, propylene, Ar and He), residence time and agitator speed (0-300 rpm) on the c...
متن کاملA novel heme-regulatory motif mediates heme-dependent degradation of the circadian factor period 2.
Although efforts have been made to identify circadian-controlled genes regulating cell cycle progression and cell death, little is known about the metabolic signals modulating circadian regulation of gene expression. We identify heme, an iron-containing prosthetic group, as a regulatory ligand controlling human Period-2 (hPer2) stability. Furthermore, we define a novel heme-regulatory motif wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Omega
سال: 2020
ISSN: 2470-1343,2470-1343
DOI: 10.1021/acsomega.0c01698